Imaging & BioInformatics Publications (Selected)
2010 Top of page.
Belmamoune, M., Potikanond, D., Verbeek, F.J. (2010)
Mining and analysing spatio-temporal patterns of gene expression in an integrative database framework.
Journal of Integrative Bioinformatics, (Accepted)
Zhang, Y., Verbeek, F.J. (2010)
Comparison and Integration of Target Prediction Algorithms for microRNA Studies.
Journal of Integrative Bioinformatics, (Accepted)
Bertens,L.M.F., Richardson, M.K., Verbeek, F.J. (2010)
Analysis of cardiac development in the turtle Emys orbicularis (Testudines: Emidydae)
using 3D computer modeling and reconstruction based on serial sections.
Anatomical Record (Accepted)
Kuan Yan, K., Bertens, L.F.M., Verbeek, F.J. (2010)
Image Registraton and Realignment using Evolutionary Algorithms with High resolution 3D model from Human Liver.
Proceedings CGIM 2010 (Eds. Sappa,A.D.) 11th IASTED International Conference on Computer Graphics and Imaging.
Innsbruck, Austria, February 2010: 679-014.
Dmitrieva, J., Verbeek, F.J. (2010)
Different Geometries in Ontology Visualization.
Proceedings SPIE EI 2010, Data and Information Visualization (Eds.)
San Jose, USA, January 2010. (In Press)
Nezhinsky, A., Kruisselbrink, J., Verbeek, F.J. (2010)
Convex Shape Retrieval from Edge Maps by the use of an Evolutionary Algorithm
1st International Conference on Bioinformatics, Valencia, Spain
Proceedings Bioinformatics 2010 (Eds.Fred,A., Filipe,J., & Gamboa,H.): 221-225
2009 Top of page.
Kallergi, A., Verbeek, F.J. (2009)
Onto-Frogger: Playing with Semantic Structure.
Proceedings Workshop on Semantic Web Applications and Tools for Life Sciences (SWAT4LS)
CEUR-Workshop Proceedings ISSN 1613-0073, http://ceur.ws.org
Volume 559 (Eds. Marshall, S.M.,Burger A.,Romano P.,Paschke A.,Splendiani A.)
Amsterdam, The Netherlands, November 20, 2009
Slob, J., Kallergi, A., Verbeek, F.J. (2009)
Observations on Semantic Annotation of Microscope Images for Life Sciences
Proceedings Workshop on Semantic Web Applications and Tools for Life Sciences (SWAT4LS)
CEUR-Workshop Proceedings ISSN 1613-0073, http://ceur.ws.org
Volume 559 (Eds. Marshall, S.M.,Burger A.,Romano P.,Paschke A.,Splendiani A.)
Amsterdam, The Netherlands, November 20, 2009
Dmitrieva, J., Verbeek, F.J. (2009)
Integration of information from different ontologies.
Proceedings Workshop on Semantic Web Applications and Tools for Life Sciences (SWAT4LS)
CEUR-Workshop Proceedings ISSN 1613-0073, http://ceur.ws.org
Volume 559 (Eds. Marshall, S.M.,Burger A.,Romano P.,Paschke A.,Splendiani A.)
Amsterdam, The Netherlands, November 20, 2009
Belmamoune, M. (2009)
Spatio-Temporal Framwork for Inegrative Analysis of Zebrafish developmental Studies.
PhD Thesis, Leiden University. ISBN 978-90-9024866
Dmitrieva, J., Verbeek, F.J. (2009)
Node-Link and Containment Methods in Ontology Visualization.
Proceedings OWLED 2009, Washington DC, USA (http://www.webont.org/owled/2009/).
Papakonstantinou, C., Ioannis Panagiotou, I., Verbeek, F.J. (2009)
Tag Based Meta-Search for Browsing the Web: The TicTag Application.
Proceedings HCI 2009, People and Computers XXIII – Celebrating people and technology.
British Computer Society, United Kingdom: 354 -361
Giannoulis, S., Verbeek, F.J. (2009)
The happiness cube paradigm; eliciting happiness through sound, video, light and odor.
Assessment of affective state with non-invasive techniques.
In: 4th International Workshop on Emotion and Computing,
in conj. with 32nd Annual Conference on Artificial Intelligence (KI2009), Paderborn, Germany: 7–14,
Zhang, Y., de Bruin, J.S., Verbeek, F.J. (2009)
Specificity Enhancement in microRNA Target Prediction through Knowledge Discovery.
(In: Machine Learning. (Eds. V. Kordic), (ISBN 978-953-7) (In Press)
Sebastiaan A. Brittijn, Suzanne J. Duivesteijn, Mounia Belmamoune, Laura F.M.Bertens, Wilbert Bitter,
Joost D. de Bruijn, Danielle L. Champagne, Edwin Cuppen, Gert Flik, Christina M. Vandenbroucke-Grauls, Richard A.J. Janssen,
Ilse M.L. de Jong, Edo Ronald de Kloet, Alexander Kros, Annemarie H. Meijer, Juriaan R. Metz, Astrid M. van der Sar,
Marcel J.M. Schaaf, Stefan Schulte-Merker, Herman P. Spaink, Paul P. Tak, Fons J. Verbeek, Margriet J. Vervoordeldonk,
Freek J. Vonk, Frans Witte, Huipin Yuan and Michael K. Richardson (2009)
Zebrafish development and regeneration: new tools for biomedical research.
Int. J. Dev. Biol. (2009) 53: 835-850
Kallergi, A., Bei, Y., Kok., P., Dijkstra, J., Abrahams, J.P., Verbeek, F.J. (2009)
Cyttron: A Virtualized Microscope supporting image integration and knowledge discovery.
In: Cell Death and Disease Series (Eds.Backendorf,Noteborn,Tavassoli):
Proteins Killing Tumour Cells, ResearchSignPost, Kerala India, 291-315
Papakonstantinou, C., Ioannis Panagiotou, I., Verbeek, F.J. (2009)
Tag Based Meta-Search for Browsing the Web: The TicTag Application.
Proceedings CHI-NL, (Eds.: Verbeek, Lenior, Steen), Leiden, The Netherlands, pg. 93-101.
Dmitrieva, J., Verbeek, F.J. (2009)
Multi-view Ontology Visualization.
Proceedings 11th International Protege Conference
(http://protege.stanford.edu/conference/2009/abstracts/S9P3Dmitrieva.pdf)
Kallergi, A., Bei, Y., Verbeek, FJ. (2009)
The Ontology Viewer: Facilitating Image Annotation with Ontology Terms in the CSIDx imaging Database.
Proceedings VISS-WS 2009, CEUR-WS Proceedings Vol. 443 (http://ceur-ws.org)
Yan, K., Le Devedec, S., van de Water, B., Verbeek, F.J. (2009)
Cell Tracking and Data Analisys of in vitro Tumour Cells from Time-Lapse Image Sequences.
Proceedings VISAPP 2009 Volume 1, 281-287.
Roël, G., Gent Y.J., Peterson-Maduro, J., Verbeek, F.J. & Destrée, O. (2009)
Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis.
International Journal of Developmental Biology 53: 81-89
Lenneke W.A van Hooijdonk, Muhammad Ichwan, Thomas F. Dijkmans, Theo G. Schouten, Fons J. Verbeek, Erno Vreugdenhil, Carlos P. Fitzsimons (2009)
Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression.
BMC Neuroscience 10:2 (13 January 2009)
2008 Top of page.
Dmitrieva, J., Verbeek F.J. (2008)
Information Visualization from Ontology
Proc. 5th international conference on formal ontology in information systems. FOIS 2008
Umanski, D., Kosters, W., Verbeek, F.J., Schiller, N.O. (2008).
Integrating computer games in speech therapy for children who stutter.
Proc. 1st Workshop Child, Computer and Interaction. Crete-Greece, October 2008 (In Press)
Zhang, Y., de Bruin, J.S., Verbeek, F.J. (2008)
miRNA Target Prediction through Mining of miRNA Relationships.
Proc. 8th IEEE Int. Conf. on BioInformatics and BioEngineering, 2008. BIBE 2008; 1 - 6.
Belmamoune M. and Verbeek, F.J. (2008)
Data Integration for Spatio-Temporal Patterns of Gene Expression of Zebrafish development:
the GEMS database.
Journal of Integrative BioInformatics, 5(2):92, 2008
Richardson et al., with Bertens, LFM., Belmamoune, M., Verbeek, FJ.(2008)
Zebrafish Developmental Patterning: New Tools for Medical Research
International Journal of Developmental Biology (Accepted)
Zhang, Yanju, Woltering, J.M., Verbeek F.J. (2008)
Screen of MicroRNA Targets in Zebrafish Using Heterogeneous Data Sources:
A Case Study for Dre-miR-10 and Dre-miR-196
International Journal of Mathematical, Physical and Engineering Sciences, Vol. 2 (1), 10 - 17.
2007 Top of page.
Bei, Y., Dmitrieva, J., Belmamoune, M., Verbeek, F.J. (2007)
Ontology Driven Image Search Engine.
Proc. SPIE Vol. 6506, MultiMedia Content Access: Algorithms & Systems (Eds Hanjalic, A., Schettini, R., Sebe, N.), 65060G-1,65060G-10
van der Putten, P., Bertens, L.F.M., Liu, J., Hagen, F., Boekhout T., Verbeek F.J. (2007)
Classification of Yeast Cells from Image Features to Evaluate Pathogen Conditions.
Proc. SPIE Vol. 6506, MultiMedia Content Access: Algorithms & Systems, Vol. 6506 (Eds Hanjalic, A., Schettini, R., Sebe, N.), 65060I-1,65060I-14
Kabli, S., Spaink, H.P., de Groot, H.J.M., Verbeek, F.J., Alia, A. (2007)
In Vivo magnetic resonance microimaging in adult zebrafish.
Proceedings International Society for Magnetic Resonance in Medicine 2007; 15: 1347.
Broekens, J., Kosters, W., Verbeek, F.J. (2007)
On Affect and Self-Adaptation: Potential Benefits of Valence-Controlled Action-Selection.
Proceedings of the 2nd. International Work-Conference on the Interplay between Natural and Artificial Computation (IWINAC 2007, Murcia, Spain) Lecture Notes in Computer Science, LNCS 4527 (pp. 357-366) Springer-Verlag.
Dmitrieva, J., Bei, Y., Verbeek, F.J. (2007)
Ontological Context Visualization. Proceedings OWLED2007.
Belmamoune, M., & Verbeek, F.J. (2007)
Developmental Anatomy Ontology of Zebrafish: an Integrative semantic framework.
Journal of Integrative Bioinformatics 4(3), 2007.
Broekens, J., Kosters, W., Verbeek, F.J. (2007)
Affect, Anticipation, and Adaptation: Affect-Controlled Selection of Anticipatory Simulation in Artificial Adaptive Agents.
Adaptive Behavior, 15(4), 397-422
Zhang, Yanju, Woltering, J.M., Verbeek F.J. (2007)
Screen of MicroRNA Targets in Zebrafish Using Heterogeneous Data Sources:
A Case Study for Dre-miR-10 and Dre-miR-196
Proceedings WASET VOLUME 26 DECEMBER 2007 , Bangkok 2007,258-265.
Welten, M.C.M. (2007)
Spatio-temporal gene expression analysis from 3D in situ hybridisation images.
PhD Thesis, Leiden University.
Broekens, J.D. (2007)
Affect and Learning: A Computational Analysis
PhD Thesis, Leiden University.
2006 Top of page.
Bei Y, Belmamoune M and Verbeek FJ. (2006)
Ontology and image semantics in multimodal imaging: submission and retrieval.
Proc. SPIE Internet Imaging VII, Vol. 6061, 60610C1-C12, 2006.
Welten, M.C.M, De Haan, S., van den Boogert, N., Noordermeer, J.N., Lamers, G., Spaink, H.P., Meijer, A.H., Verbeek, F.J. (2006)
ZebraFISH: Fluorescent in situ hybridization protocol and 3D images of gene expression patterns. Zebrafish, Vol 3. #4, pp 465 - 476.
Kabli, S., Alia, A., Spaink, H.P., Verbeek, F.J., de Groot, H.J.M. (2006)
Magnetic Resonance Microscopy of the Adult Zebrafish.
Zebrafish, Vol 3., #4, pp 431 - 439
Braakman, N., Matysik, J., van Duinen, S.G., Verbeek, F.J., Schliebs, R., de Groot, H.J.M., Alia, A.(2006)
Longitudinal Assessment of Alzheimers ß-Amyloid Plaque Development in Transgenic Mice Monitored by In Vivo Magnetic Resonance Microimaging.
Journal of Magnetic Resonance Imaging VOl 24., 530 - 536.
Diks, S.H. Bink, R.J., van de Water, S., Joore, J., Verbeek, F.J., den Hertog J., Peppelenbosch, M.P., Zivkovic, D. (2006)
The novel gene, asb11: a regulator of the size of the neural progenitor compartment
Journal of Cell Biology Vol. 174(4); pp 581-592
Meuleman, W., Welten, M.C., Verbeek, F.J. (2006)
Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients.
Lecture Notes in Computer Science, Volume 4216, Computational Life Sciences II, pp 236-246.
Belmamoune, M. and Verbeek, F.J. (2006)
Heterogeneous Information Systems: bridging the gap of time and space. Management and retrieval of spatio-temporal Gene Expression data.
In: InSCit2006 (Ed. Vicente P. Guerrero-Bote), Volume I "Current Research in Information Sciences and Technologies. Multidisciplinary approaches to global information systems", pp 53-58.
Belmamoune, M., Lindoorn, L. and Verbeek, F.J. (2006)
3D-VisQuS: A 3D Visual Query System integrating semantic and geometric models.
In: InSCit2006 (Ed. Vicente P. Guerrero-Bote), Volume II "Current Research in Information Sciences and Technologies. Multidisciplinary approaches to global information systems", pp 401-405.
Broekens, Joost, Kosters, Walter A., Verbeek, Fons J. (2006) On Emotion, Anticipation and Adaptation: Investigating the Potential of Affect-Controlled Selection of Anticipatory Simulation in Artificial Adaptive Agents. Adaptive Behavior (Special Issue on Mechanisms for Action Selection) (Accepted)
Mubarak Q., Dmitrieva J., Vermeulen T., Zhou Y., Groenewegen L., Basmagi, S., van Beek R., Verbeek F.J.(2006)
BioTune, a component based repository of BioInformatics teaching modules.
Proceedings MICTE 2006 (Eds. Méndez-Vilas, A., Solano Martin, A., Mesa Gonzalez, JA., Mesa Gonzalez, J.) "Current Developments in Technology-Assisted Education" , Sevilla 2006, FormaText, pp. 1186 -1192
Liu, J., van der Putten, P., Hagen, F., Chen, X., Boekhout, T., and F.J. Verbeek F.J. (2006),
Detecting virulent cells of Cryptococcus neoformans yeast: clustering experiments,
Proceedings ICPR Volume 1 IEEE Computer Society 2006, 1112- 1115, Hongkong , China.
2005 Top of page.
de Jonge H.W., de Bakker M.A.G., Verbeek F.J., Weijs W.A. (2005)
Embedding of large specimens in air sensitive glycol methacrylate: Prerequisites for multi-signal detection and high-resolution imaging.
Microscopy Research and Techniques 2005 Jan 1;66(1):25-30.
Welten M.C.M., Verbeek F.J., Meijer A.H., Richardson M.K. (2005)
Gene expression and digit homology in the chicken embryo wing.
Evolution & Development 2005 (#1):18-28
Meijer AH, Verbeek FJ, Salas-Vidal E, Corredor-Adamez M, Bussman J, van der Sar AM, Otto GW, Geisler R, Spaink HP (2005).
Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection.
Mol Immunol. 2005 Jun;42(10):1185-203.
Corredor-Adámez M., Welten, M.C.M. , Spaink, H.P., Jeffery, J.E. ,Schoon, R.T. ,de Bakker, M.A.G. Bagowski, C.P., Meijer, A.H. , Verbeek, F.J. and Richardson. M.K. (2005).
Genomic annotation and transcriptome analysis of the Danio rerio hox complex with description of a novel member, hoxb13a.
Evolution & Development 2005 (#5):362-375
Joost Broekens and Fons J. Verbeek (2005)
Simulation, Emotion and Information Processing: Computational Investigations of the Regulative Role of Pleasure in Adaptive Behavior Modeling Natural Action Selection.
Proceedings MNAS Workshop, Edinburgh, UK.
2003-2004 Top of page.
Verbeek,F.J., Rodrigues,D.D., Spaink H., Siebes A (2004) Data submission of 3D image sets to a bio-molecular database using active shape models and a 3D reference model for projection. In: Proceedings SPIE 5304, Internet Imaging V. 13-23.
Richardson, M.K., Verbeek, F.J. (2003) New Directions in Comparative Embryology and the Nature of Developmental Characters. Animal Biology 53 303-311.
2001 - 2002 Top of page.
Verbeek, F.J., Boon, P.J., Sloetjes, H., van der Velde, R., de Vos, N. (2002). Visualization of complex data sets over Internet: 2D and 3D visualization of the 3D digital atlas of zebrafish development. Proceedings SPIE 4672, Internet Imaging III. 20-29
Verbeek, F.J., Boon, P.J. (2002) High Resolution 3D Reconstruction from serial sections. Microscope instrumentation, software design and its implementations. In: Proceedings SPIE 4621, Three Dimensional and Multi Dimensional Microscopy. Image Acquisition and Processing IX. 65-76
Voncken, F., Tjaden, J., Boxma, B., Akhmanova, A., Veenhuis, M., Huynen, M., Verbeek, F.J., Tielens, A.G.M., Haferkamp, I., Neuhaus, E., Vogels, G., & Hackstein. J.H.P. (2002) Multiple origins of hydrogenosomes: A mitochondrial-type ADP/ATP carrier in the hydrogenosomes of the anaerobic chytrid Neocallimastix sp. L2. Molecular Microbiology 264(3) 273-83.
Allen, S.P., Bogardi, J.-P., Barlow, A.J., Saaidia, A., Qayyum, S.R., Verbeek, F.J., Anderson, R.H., Francis West, P.H., Brown, N., and Richardson M.K. (2001). Misexpression of Noggin Leads to Septal Defects in the Outflow Tract of the Chick Heart. Developemental Biology 235, 98-109.
Qayyum, S.R., Webb, S., Brown, N., Anderson, R.H., Verbeek, F.J., and Richardson M.K. (2001). Septation and Valval Formation in the Outflow Tract of the Embryonic Chick Heart.
Anatomical Record. 264(3) 273-283
ten Berge, D., Brouwer, A., Korving, J., Reijnen, M.J., van Raaij, E.J., Verbeek, F.J., Gatfield, W., and Meijlink, F. (2001). Prx1 and Prx2 are upstream regulators of Sonic hedgehog, and control cell proliferation during mandibular arch morphogenesis. Development 128, 2929-2938.
van Raaij, E.J., ten Berge, D., Hage, W.J., Brouwer, A., Maintz, J.B.A., and Verbeek, F.J. (2001). Automated Topographical Cell Proliferation Analysis. Cytometry 45, 13-18.
1996-2000 Top of page.
Boon, P.J., Eminovic, N., de Vos, A., Buitendijk, B., van Raaij, E.J., Hage, W.J., and Verbeek, F.J. (2000). A virtual lab-notebook for multi-dimensional microscope images. IEEE Comp.Soc.Press, Proceedings Information Visualisation 4, 187-191.
Verbeek, F.J., den Broeder, M.J., Boon, P.J., Buitendijk, B., Doerry, E., van Raaij, E.J., and Zivkovic, D. (2000). A standard atlas of zebrafish embryonic development for projection of experimental data. Proceedings of SPIE 3964, 242-252.
Baldock, R.A., Verbeek, F.J., and Vonesh, J.L. (1997). 3D reconstructions for graphical databases of gene-expression. Seminars in Cell & Developmental Biology 8, 499-507.
Griffini, P., Smorenburg, S.M., Verbeek, F.J., and van Noorden, C.J.F. (1997). Three-Dimensional reconstruction of colon carcinoma metastasis in Liver. J.Microscopy 169, 375-382.
Lamers, W.H., Geerts, W.J., Jonker, A., Verbeek, F.J., Wagenaar, G.T., and Moorman, A.F. (1997). Quantitative graphical description of portocentral gradients in hepatic gene expression by image analysis.
Hepatology 26, 398-406.
van Raaij, E.J., Boon, P.J., Maintz, J.B.A., and Verbeek, F.J. (1999). Composition of high resolution image mosaics for 3D reconstruction from serial sections. In Biomedical Image Registration. F. Pernus, S. Kovcic, H.S. Stiehl, and M.A. Viergever, eds. 262-271.
Verbeek, F.J., Lawson, K.A., and Bard, J.B.L. (1999). Developmental BioInformatics: linking genetic data to virtual embryos. Int.J.Dev.Biol. 43, 761-771.
Verbeek, F.J. (1999). Theory & Practice of 3D-reconstructions from serial sections. In Image Processing, A Practical Approach. R.A. Baldock and J. Graham, eds. (Oxford: Oxford University Press), pp. 153-195.
Nievelstein, R.A.J., Werf, v.d., Vermeij-Kiers, C., Verbeek, F.J., and Valk, J. (1998). Normal and abnormal embryonic development of the anorectum in human embryos. Teratology 57, 70-78.
Verbeek, F.J. and Huijsmans, D.P. (1998). A Graphical database for 3D reconstruction supporting 4 different Geometrical Representations. In Medical Image Databases. S.T.C. Wong, ed. (Boston: Kluwer Academic Publishers), pp. 117-144.
Verbeek, F.J. (1996). 3D reconstruction from serial sections, applications and limitations. Microscopy and Analysis 96-11, 33-35.
Roshani, H., Dabhoiwala, N.F., Verbeek, F.J., and Lamers, W.H. (1996). Functional Anatomy of the Human Uterovesical Junction. Anatomical Record 245, 645-651.
1992-1995 Top of page.
Verbeek, F.J. (1995). Three dimensional reconstruction from serial sections including deformation correction (Delft: Delft University of Technology).
Verbeek, F.J., Huijsmans, D.P., Baeten, R.W.A.M., Schoutsen, C.M., and Lamers, W.H. (1995). Design and implementation of a program for 3D-reconstruction from serial sections; a data-driven approach. Microscopy Research and Technique 30, 496-512.
Smith, A., Connell, M.G., Jackson, M., Verbeek, F.J., and Anderson, R.H. (1994).
Atrioventricular conduction system in hearts with muscular ventricular septal defects in the setting of complete transposition.
J.Thorac.Cardiovasc.Surg. 108, 9-16.
Wagenaar, G.T., Moorman, A.F.M., Chamuleau, R.A.F.M., Deutz, N.E.P., de Gier, C., de Boer, P.A.J., Verbeek, F.J., and Lamers, W.H. (1994).
Vascular branching pattern and zonation of gene-experession in the mammalian liver; a comparative study in rat, mouse, cynomolgus monkey, and pig.
Anatomical Record 239, 441-452.
Manders, E.M.M., Verbeek, F.J., and Aten, J.A. (1993). Measurement of co-localisation of objects in dual colour confocal images. J.Microscopy 169, 375-382.
Verbeek, F. J. and Mullikin, J. C. (1993) Extraction of Shape Features from the Vector Distance Transform. Proc. Int. Conf. Volume Image Processing., 149-151
Verbeek, F.J., de Groot, M.M., Huijsmans, D.P., Lamers, W.H., and Young, I.T. (1993). 3D BASE: A geometrical database system for the analysis and visualisation of 3D shapes obtained from parallel serial sections including three different geometrical representations. Computerised Medical Imaging and Graphics 17, 151-163.
Verbeek, F. J. Deformation correction using Euclidean contour distance maps. (1992)
IEEE Comp.Soc.Press, Proceedings 11th Int.Conf.on Pattern Recognition 3, 347-351.
Lamers, W.H., Wessels, A., Verbeek, F.J., Moorman, A.F.M., Viragh, S., Wenink, A.C.G., Gittenberger-de Groot, A.C., and Anderson, R.H. (1992).
New findings concerning ventricular septation in the human heart - their implications for maldevelopment. Circulation 86, 1194-1205.
Wessels, A., Vermeulen, J.L., Verbeek, F.J., Viragh, S., Kalman, F., Lamers, W.H., and Moorman, A.F. (1992).
Spatial distribution of "tissue-specific" antigens in the developing human heart and skeletal muscle. III.
An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system. Anatomical Record 232, 97-111.